Targeting Energy Metabolic and Oncogenic Signaling Pathways in Triple-negative Breast Cancer by a Novel Ampk Activator

TARGETING ENERGY METABOLIC AND ONCOGENIC SIGNALING PATHWAYS IN TRIPLE-NEGATIVE BREAST CANCER BY A NOVEL AMPK ACTIVATOR Kuen-Haur Lee, En-Chi Hsu, Jih-Hwa Guh, Hsiao-Ching Yang, Dasheng Wang, Samuel K. Kulp, Charles L. Shapiro, and Ching-Shih Chen From Division of Medicinal Chemistry, College of Pharmacy, and Division of Medical Oncology, College of Medicine, The Ohio State University, Columbus, Ohio; School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan; Department of Chemistry, Fu-Jen Catholic University, Hsinchuang, Taipei, Taiwan Running head: Antitumor effects of a novel AMPK activator in TNBC cells Address Correspondence to: Ching-Shih Chen, College of Pharmacy, 336 Parks Hall, The Ohio State University, 500 West 12 Avenue, Columbus, OH 43210-1291. Phone: 614-688-4008; Fax: 614-6888556; E-mail: [email protected]